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Chancroid STD IntroductionIntroduction Chancroid is a sexually transmitted disease (STD) caused by the Gram negative bacterium Haemophilus ducreyi. It is characterized by necrotizing genital ulceration and may be accompanied by inguinal lymphadenitis or bubo formation. Chancroid may also be spread to other anatomical sites by auto-inoculation. H ducreyi is difficult to culture from ulcer. DNA amplification techniques are accurate but not generally available. Chancroid in the tropics is usually treated with erythromycin. Single dose regimens with other antibiotics are available. Genital ulceration from any disease is associated with increased transmission of human immunodeficiency virus. Therefore treatment of chancroid is important to control the spread of HIV infection in third world countries. Chancroid occurs sporadically in developed countries in individuals who have returned from endemic areas or who have had contact with prostitutes. Chancroid is a major cause of genital ulceration in South East Asia and Africa. |