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Previous HSV type 1 infectionPrevious HSV type 1 infection
Previous infection with HSV type 1 reduces the rate of acquisition of genital HSV type 2 infection, reduces the severity of initial HSV type 2 infection, and may increase the proportion of persons acquiring HSV type 2 asymptomatically or subclinically. The presence of HSV type 1 antibody is associated with a decreased likelihood of detecting antibody to HSV type 2 in women.
Genital infections HSV-1.
Genital infections with HSV-1 are associated with less asymptomatic shedding, lower rates of clinical recurrence, and lower rates of transmission.
HIV infection
The rates of herpes simplex virus (HSV) infection are rising, the highest prevalence being in the group infected with the human immunodeficiency virus (HIV). Genital ulcer disease is a risk factor in the transmission of the human immunodeficiency virus 1 (HIV-1). HIV-1 virions can be detected in genital ulcers caused by HSV-2, which suggests that genital herpes infection likely increases the efficiency of the sexual transmission of HIV-1. The treatment of genital herpes decreases the rates of HIV infection.
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