Keratoacanthoma Information and Causes
Keratoacanthoma is a rapidly growing crateriform nodule with a distinctive clinical appearance that is best regarded as a low-grade squamous cell carcinoma. The peak incidence of keratoacanthoma is between ages 50 and 70. This tumor is rare before 40 years of age. Caucasians with fair complexions are most often affected.
Chemical exposure and human papillomavirus have been implicated as a cause in animal models, although their role in humans is controversial. Historically, keratoacanthomas have been regarded as benign regressing lesions, however, they should be thought of as variants of squamous cell carcinoma and treated as such.