Skin Cancer Cutaneous T-cell Lymphoma Erythrodermic stage (Sezary syndrome)
Erythrodermic patients, present with total body redness. This presentation of CTCL is called the Sezary syndrome. The differential diagnosis of erythroderma includes psoriasis, pityriasis rubra pilaris, seborrheic dermatitis, and severe drug reactions. The erythrodermic stage can progress from any stage or appear without any previous skin findings. The skin is diffusely red and scaly. The palms and soles may become very thick and crack, making it difficult to walk. Alopecia and ectropion are common, exfoliation and heat loss thru the skin are worrisome and infiltration of the lymph nodes occurs. Many of these patients have generalized pruritus and shaking chills at presentation. There are more than 1000 per mm3 atypical T lymphocytes with cerebriform nuclei circulating in the peripheral blood. SS occurs in 5% of all cases of MF.