Skin Metastasis Lymphoma, leukemia | Dermatology Education Skin Metastasis Lymphoma, leukemia Video
January 18, 2022

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  • Skin Metastasis Lymphoma, leukemia


    Cutaneous metastases occur in 6.5% of all patients with lymphoma. A skin lesion is the presenting sign in 5% of patients and the first sign of extranodal disease in 7.5% of patients. These appear as firm, raised, smooth, red to violaceous nodules and plaques, that may ulcerate. It may be difficult to discern primary lymphoma arising in skin from metastatic disease


    Leukemia cutis is the cutaneous manifestation of leukemia on the skin and may appear as macules, papules, ecchymoses, palpable purpura, or even ulceration. It often precedes or is concurrent with a diagnosis of systemic leukemia. Adult T-cell leukemia involves the skin in 75% of patients. Lesions are seen in 25% to 30% of infants with congenital leukemias and may precede other manifestations of leukemia by up to 4 months. A unique form of leukemia cutis is myeloblastoma. This entity may occur in acute myelocytic leukemia and is one of the few skin lesions that is greenish color (chloromas). This is due to myeloperoxidase within the lesions.